Hydrogen-Enriched Water & Oral Health: A Summary of Studies

Last Updated on: June 16, 2022

Hydrogen-enriched water, or hydrogen-enriched water, has been shown to help with many health issues, but did you know that hydrogen-enriched water can also improve your oral health? Numerous studies show that it can help heal a variety of oral health issues, from cavities to oral cancers.

If you’ve ever experienced tooth problems or inflammation in your gums, you know how painful these oral health issues can be, possibly leading to cavities, headaches, infection, and even tooth loosening or loss. But did you know that dental and oral health issues can also affect your whole body? This is because the mouth is full of bacteria, some of which can cause disease when they travel from the mouth to the digestive and respiratory systems. (1) In fact, some studies suggest that oral bacteria may contribute to diseases like (1):

  • Endocarditis, an infection of the heart chambers or valves
  • Cardiovascular disease
  • Pregnancy and birth complications (premature birth and low birth weight)
  • Pneumonia

Caring for your mouth, then, is not only about having a beautiful smile or the confidence that goes with it. It’s about achieving and maintaining oral health as a way to help keep the rest of your body healthy. Along with following your dentist’s recommendations, another way to keep your mouth healthy is to drink Hydrogen-enriched water, also known as hydrogen-enriched water.

What Is Hydrogen-Enriched Water?

Hydrogen-enriched water is water infused with molecular hydrogen, which fights inflammation and oxidative stress throughout the body. Inflammation contributes to many diseases, and oxidative stress occurs when there are more harmful free radicals in your body than antioxidants to fight them. Molecular hydrogen, a powerful antioxidant, can lessen inflammation and neutralize oxidative stress. Some studies refer to hydrogen-enriched water as electrolyzed hydrogen water. These terms are synonymous.

The molecular hydrogen in hydrogen-enriched water can lessen inflammation and neutralize germs.

Dental and Oral Diseases That Hydrogen-Enriched Water Helps

Ranging from cavities to oral cancers, there are several dental and oral health conditions that hydrogen-enriched water has been shown to help.

Dental Caries/Cavities

Dental caries, also called tooth decay, occur when bacteria produce acids that attack a tooth’s enamel. Eventually, repeated bouts of these attacks will weaken the enamel and can lead to a cavity — a small hole — developing in that tooth. Untreated cavities can result in pain, infection, and even tooth loss. (2)

A study called “Neutral Electrolyzed Water for Prevention of Dental Caries” tested whether gargling with electrolyzed water (hydrogen-enriched water) could eliminate bacteria that cause dental caries. Researchers cultivated bacteria and then treated them with electrolyzed water. They found that electrolyzed water exhibited antibacterial activity and killed more bacteria than commercial solutions. The scientists concluded that electrolyzed water may be useful in preventing dental caries, especially for children, since traditional commercial gargling solutions can have harmful side effects if swallowed. (3)

Oral Wounds

A study published by the Department of Preventive Dentistry at Tokushima University Graduate School in Japan looked at whether hydrogen-enriched water could initiate oral wound healing. To determine this, 24 rats with oral wounds were examined. Distilled water was given to 12 of the rats, and the remaining 12 were given hydrogen-enriched water. The group that consumed hydrogen-enriched water experienced accelerated wound healing compared to the group that consumed distilled water. (4)

In addition, the rats that consumed hydrogen-enriched water showed reduced proinflammatory cytokines, which are molecules that cause inflammation. Hydrogen-enriched water not only helped reduce wound inflammation, it helped produce an antioxidant response to the wounds as a defense mechanism. The final results of this study, then, show that drinking hydrogen-enriched water speeds healing of oral wounds. (4, 5, 6)

Gingivitis and Periodontitis

“Gingiva” refers to gum tissue that both surrounds the base of the teeth and connects to the alveolar bone (the part of the jawbone that supports the teeth). (7, 8)

Gingivitis is the inflammation of these gum tissues. If not promptly treated, gingivitis can lead to periodontitis, which is a severe form of gingivitis — gingivitis itself is acute while periodontitis is chronic and can lead to tooth loss. (9, 10)

In a study titled “Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria,” scientists noted that of the 700 types of bacteria in the mouth, many are responsible for oral diseases. They recognized that hydrogen-enriched water “has been shown to have beneficial effects on human immunity” and aimed to determine whether it could fight oral bacteria associated with disease. (11)

In a growth medium, the researchers cultivated bacteria normally found in the mouth. Part of each colony was soaked in tap water for 30 seconds, and the remaining parts were soaked in hydrogen-enriched water for 30 seconds. Forty-eight hours later, the numbers of bacterial colonies were then measured, and those that had been soaked in hydrogen water showed antibacterial activity against all strains compared to those soaked in tap water. The researchers concluded that hydrogen water can positively impact oral hygiene by helping to remove disease-causing oral bacteria. (11)

The “Journal of Visualized Experiments” published a similar study using a rat model to study what the researchers called “aggressive periodontitis.” (9) In this experiment, scientists studied the neutrophil response in rats with inflammation in the mandibular and molar areas. Neutrophils are a type of white blood cell, and their job is to digest harmful microbes to help heal wounds and fight infections. If your body has high levels of neutrophils, you are fighting an infection. (9, 12, 13)

In this study, the rats in the control group were given distilled water for three days, and the rats in the treatment group were given electrolyzed water for three days. Scientists found that the treatment group showed significantly lower neutrophil levels than the control group, indicating that electrolyzed water reduces inflammation and is effective against periodontitis. (9)

Hydrogen-enriched water has been shown to kill bacteria in infected root canals.

Infected Root Canals

Inside your teeth is a soft core referred to as dental pulp, and this pulp contains blood vessels and nerves that extend into the two roots, or canals, of each tooth. When a tooth develops a crack or cavity, bacteria can enter the canals and lead to infection, death of the pulp, and eventually tooth loss if the crack or cavity is not treated. You may experience headaches and pain and swelling around the affected tooth. (14)

A study in the journal “Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology” aimed to determine whether hydrogen-enriched water could kill bacteria in infected root canals. The researchers isolated 15 strains of bacteria from infected root canals. Each type of bacteria was mixed with electrolyzed water for one minute and allowed to incubate for up to seven days. Results showed that the electrolyzed water inhibited the growth of the bacteria because of its constant oxidation-reduction potential (that is, its ability to neutralize microorganisms). (15) In addition, not only did the electrolyzed water inhibit bacterial growth, it exhibited germicidal properties against the bacteria. (14, 15)

Cleaning of Dentures

A study titled “Efficacy of newly developed denture cleaning device on physical properties of denture material and Candida biofilm” looked at whether electrolyzed water would be effective in cleaning dentures without the side effects caused by accidentally misusing traditional chemical cleansers. To test this, researchers placed Candida albicans (a type of fungus found naturally in the mouth and gut) on disks of denture material and allowed the fungus to grow. (16, 17) They then treated some of the disks with traditional denture cleaner, some with tap water, and some with electrolyzed water for 150 days. Results showed that using a denture cleaning device with electrolyzed water was safer than using traditional chemical cleansers.


In a study published in “Human Cell,” researchers examined whether hydrogen nano-bubbles mixed with platinum-povidone could inhibit the proliferation of human esophageal and tongue cancer cells. The researchers first administered hydrogen nano-bubbles and platinum-povidone separately to two different groups. Following this, they administered the hydrogen nano-bubbles and platinum-povidone together. These scientists found that when administered together, the hydrogen nano-bubbles and the platinum-povidone were more intensely carcinostatic — that is, the combination of the two showed an increased ability to inhibit tumor growth versus each ingredient on its own. The researchers also concluded that the hydrogen nano-bubble/platinum-povidone mixture reduced cancer therapy side effects on normal cells. (18, 19)

The “Oncology Research” journal also published a study on hydrogen-enriched water and cancer of the tongue. The scientists found that hydrogen-enriched water reduced harmful free radicals in the mouth and inhibited both the formation and size of human tongue cancer cell colonies without negative effects on the surrounding normal cells. These conclusions suggested that hydrogen-enriched water could prevent tumor growth and invasion. (20)

How You Can Get Hydrogen-Enriched Water

If you’re impressed by this evidence and want to know more, Synergy Science™ is ready to provide help and answers. Along with this, Synergy Science™ offers a line of machines called Echo Water® Machines that provide hydrogen-enriched water right in your home. In the description of each one, you’ll be able to read more about the myriad positive health benefits of hydrogen-enriched water and choose which machine is right for a healthier you.

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